By HumaSpan Research Team
April 21st 2025
Women Worldwide, Including Top Celebrities, Are Embracing This All-Natural, Research-Based Anti-Aging Nutrient That Naturally Reactivates 7 Anti-Aging Genes To Look and Feel Beautiful
Everyone knows and accepts that aging is a natural part of life.
But do we really have to accept feeling weaker, more tired, more fragile, and less alive with each passing year?
Do we need to settle for dull skin, deepening wrinkles, achy joints, constant fatigue, weaker muscles, and persistent brain fog?
Absolutely not!
That’s why millions of people desperately turn to anti-aging creams, expensive cosmetic procedures, surgeries, Botox injections, and artificial supplements that could be potentially dangerous.
Everyone knows and accepts that aging is a natural part of life.
But do we really have to accept feeling weaker, more tired, more fragile, and less alive with each passing year?
Do we need to settle for dull skin, deepening wrinkles, achy joints, constant fatigue, weaker muscles, and persistent brain fog?
Absolutely not!
That’s why millions of people desperately turn to anti-aging creams, expensive cosmetic procedures, surgeries, Botox injections, and artificial supplements that could be potentially dangerous.
But what if there was a natural, holistic way to genuinely feel younger again—to regain energy, smooth away wrinkles, strengthen muscles, clear your mind, and simply enjoy life as you once did?
After years of groundbreaking research, scientists at prestigious institutions like Harvard, Mayo Clinic, and PubMed have uncovered the real root cause behind age-related decline and visible signs of aging.
They’ve identified 7 key anti-aging genes in the body that play a vital role in keeping you youthful, vibrant, and beautiful.
These 7 genes are responsible for repairing damaged DNA, renewing skin cells to smooth wrinkles and restore glow, revitalizing hair follicles for healthier, fuller-looking hair, maintaining muscle tone and strength, sustaining all-day energy and natural vitality, sharpening memory and focus, and supporting a strong, balanced immune system.
However, as we age, these essential genes gradually become inactive or dysfunctional. As a result, you begin to notice wrinkles, sagging skin, persistent fatigue, brain fog, weaker muscles, slower metabolism, and reduced immunity.
They’ve identified 7 key anti-aging genes in the body that play a vital role in keeping you youthful, vibrant, and beautiful.
These 7 genes are responsible for repairing damaged DNA, renewing skin cells to smooth wrinkles and restore glow, revitalizing hair follicles for healthier, fuller-looking hair, maintaining muscle tone and strength,
sustaining all-day energy and natural vitality, sharpening memory and focus, and supporting a strong, balanced immune system.
However, as we age, these essential genes gradually become inactive or dysfunctional. As a result, you begin to notice wrinkles, sagging skin, persistent fatigue, brain fog, weaker muscles, slower metabolism, and reduced immunity.
The good news? Scientists have identified a specific anti-aging nutrient that can help reactivate all 7 of these dormant anti-aging genes, no matter your age.
Once reactivated, these 7 anti-aging genes trigger a powerful cascade of biological processes such as DNA repair, enhanced metabolism, cellular regeneration, and immune restoration—helping to reverse multiple signs of aging naturally and from within.
Thousands of people worldwide, including top celebrities, are already embracing this breakthrough to feel younger and beautiful without relying on harsh treatments or artificial fixes.
Here Are the 7 Anti-Aging Genes That Become Inactive After 40, Causing Accelerated Aging…
We know there are thousands of genes in our bodies, but scientists have found that only a small family of 7 powerful genes are responsible for anti-aging functions in our body.
These genes, known as Sirtuins (SIRT1–SIRT7), are often referred to as your body's “longevity genes.”
However, as we age, these essential genes become less active or even dormant.
When this occurs, our body's ability to repair, renew, and defend itself weakens, resulting in visible signs of aging and reduced vitality.
Recently, scientists have discovered specific nutrients that can reactivate these longevity genes.
We know there are thousands of genes in our bodies, but scientists have found that only a small family of 7 powerful genes are responsible for anti-aging functions in our body.
These genes, known as Sirtuins (SIRT1–SIRT7), are often referred to as your body's “longevity genes.”
However, as we age, these essential genes become less active or even dormant.
When this occurs, our body's ability to repair, renew, and defend itself weakens, resulting in visible signs of aging and reduced vitality.
Recently, scientists have discovered specific nutrients that can reactivate these longevity genes.
Once these 7 anti-aging genes are reactivated, they trigger powerful biological processes that help restore youthful, glowing skin, smooth wrinkles, promote healthier and fuller-looking hair, maintain muscle tone and strength, boost energy and vitality, enhance mental clarity and focus, and support a robust, balanced immune system.
Before we reveal the all-natural nutrient capable of reactivating these anti-aging genes, let’s briefly explore exactly what these genes do and how they help keep your body looking and feeling younger and healthier.
SIRT1 – The Skin & Hair Beauty Gene - This gene is essential for repairing damaged DNA, controlling inflammation, and managing your body's response to stress.
As we age and SIRT1 becomes less active, DNA damage accumulates, inflammation increases, and you start experiencing dull, tired-looking skin, thinning hair, persistent fatigue, and accelerated visible aging.
SIRT2 – The Brain & Focus Gene - SIRT2 maintains cognitive clarity and supports the health of your brain and nerve cells.
When this gene becomes inactive with age, you begin noticing increased brain fog, forgetfulness, slower mental processing, and diminished cognitive sharpness.
SIRT3 – The Energy Vitality Gene - This gene energizes your cells by boosting mitochondrial function, helping your body generate energy efficiently and reducing oxidative stress.
As SIRT3 activity declines with age, you start feeling sluggish, drained, and less resilient to daily stressors and physical activity.
SIRT4 – The Healthy Metabolism Gene - SIRT4 regulates your metabolism, efficiently managing the way your body processes fats and sugars.
As you age and this gene's activity decreases, your metabolism slows, leading to weight gain, reduced energy levels, stubborn fat storage, and increased metabolic challenges.
SIRT5 – The Detox & Immunity Strength Gene - SIRT5 detoxifies your cells and strengthens your immune responses.
When this gene's activity slows with age, your body struggles to effectively eliminate toxins, weakening your immunity and making you more prone to illness and slower recovery.
SIRT6 – The Radiant Skin Repair Gene - SIRT6 plays a key role in maintaining DNA health and skin elasticity, actively repairing damage caused by environmental stressors.
Reduced activity of SIRT6 with age leads to dull, wrinkled, sagging skin, accelerating visible skin aging and reducing your skin’s youthful glow.
SIRT7 – The Youthful Cell Renewal Gene - SIRT7 promotes healthy cell division and supports the regeneration of youthful, vibrant cells throughout your body.
As you age and this gene becomes dormant, your body's ability to produce new, healthy cells diminishes, resulting in premature cellular aging and a reduction in your overall vitality and youthful appearance.
Research-Based, All-Natural Nutrient to Reactivate These 7 Anti-Aging Genes and Naturally Start Looking and Feeling Younger
As we age, these 7 anti-aging genes become dysfunctional or inactive, causing both visible and internal signs of aging, such as wrinkles, sagging skin, constant fatigue, brain fog, cognitive decline, muscle weakness, weakened immunity, and other age-related issues.
Groundbreaking research and clinical trials from prestigious institutions like Harvard, Mayo Clinic, PubMed, and the NIH have found that these anti-aging genes require a specific nutrient, NAD+, to stay active and functional.
NAD+ (Nicotinamide Adenine Dinucleotide) is a natural molecule already present in your body.
As we age, these 7 anti-aging genes become dysfunctional or inactive, causing both visible and internal signs of aging, such as wrinkles, sagging skin, constant fatigue, brain fog, cognitive decline, muscle weakness, weakened immunity, and other age-related issues.
Groundbreaking research and clinical trials from prestigious institutions like Harvard, Mayo Clinic, PubMed, and the NIH have found that these anti-aging genes require a specific nutrient, NAD+, to stay active and functional.
NAD+ (Nicotinamide Adenine Dinucleotide) is a natural molecule already present in your body.
Often called your body's “youth molecule,” NAD+ uniquely activates these 7 anti-aging genes.
When you're young, your body naturally produces abundant NAD+, efficiently supporting these anti-aging genes. With sufficient NAD+, these genes function optimally, effortlessly maintaining your youthful appearance and energy.
However, as you age, your NAD+ levels drastically decline—often by as much as 80–90%. This sharp drop in NAD+ causes the anti-aging genes to become inactive, accelerating the aging process.
Researchers have discovered that restoring NAD+ levels can reactivate these dormant anti-aging genes, restarting powerful biological processes including DNA repair, cellular regeneration, autophagy (cellular cleanup), and inflammation control.
When you're young, your body naturally produces abundant NAD+, efficiently supporting these anti-aging genes. With sufficient NAD+, these genes function optimally, effortlessly maintaining your youthful appearance and energy.
However, as you age, your NAD+ levels drastically decline—often by as much as 80–90%.
This sharp drop in NAD+ causes the anti-aging genes to become inactive, accelerating the aging process.
Researchers have discovered that restoring NAD+ levels can reactivate these dormant anti-aging genes, restarting powerful biological processes including DNA repair, cellular regeneration, autophagy (cellular cleanup), and inflammation control.
But there’s a challenge: directly supplementing NAD+ isn't effective because it breaks down in the stomach before reaching your cells.
That's why scientists have tested NMN (Nicotinamide Mononucleotide)—a naturally occurring molecule your body uses to produce NAD+.
Although NMN exists in small amounts in foods like broccoli and avocado, dietary intake alone isn't sufficient to restore optimal NAD+ levels.
Clinical trials confirm that supplementing with 1000mg of NMN effectively restores NAD+ levels.
As NAD+ is replenished, the 7 anti-aging genes are reactivated, naturally triggering biological processes that regenerate and repair your body from within.
That's why scientists have tested NMN (Nicotinamide Mononucleotide)—a naturally occurring molecule your body uses to produce NAD+.
Although NMN exists in small amounts in foods like broccoli and avocado, dietary intake alone isn't sufficient to restore optimal NAD+ levels.
Clinical trials confirm that supplementing with 1000mg of NMN effectively restores NAD+ levels.
As NAD+ is replenished, the 7 anti-aging genes are reactivated, naturally triggering biological processes that regenerate and repair your body from within.
Once these powerful anti-aging processes resume, you'll experience remarkable benefits: smoother, firmer skin, stronger muscles, sharper cognitive clarity, increased energy, and enhanced immunity. You naturally look and feel younger, more vibrant, and energized from the inside out.
Remarkable Anti-Aging Benefits You’ll Experience as These 7 Dormant Anti-Aging Genes Reactivate with Higher NMN/NAD+ Levels
As your NAD+ levels rise with daily NMN supplementation, your body begins to reactivate 7 powerful anti-aging genes that have been dormant for years.
Once these genes become active again, they trigger a powerful anti-aging biological process that repairs your cells, regenerates tissues, and enhances your overall health, energy, and vitality.
Here's exactly what happens as your NAD+ levels are restored with NMN supplementation:
First, the Skin & Hair Beauty Gene (SIRT1) is reactivated.
This gene repairs damaged DNA and reduces inflammation, vital for healthy, youthful skin and hair.
As NAD+ levels initially rise, SIRT1 reactivates, slowing cellular damage, stabilizing stress responses, and rejuvenating your appearance from the inside out.
You'll notice reduced fatigue, quicker recovery, and visibly glowing, youthful skin.
Next, the Brain & Nerve Clarity Gene (SIRT2) becomes active.
SIRT2 protects brain and nerve cells, sharpening cognitive functions.
With sufficient NMN/NAD+ to support SIRT2, this gene enhances mental clarity, reduces brain fog, and sharpens your focus. You'll experience improved memory, concentration, and clearer thinking.
Soon after, the Energy Vitality Gene (SIRT3) restarts.
SIRT3 energizes your mitochondria, your body’s natural energy powerhouses.
As sufficient NMN/NAD+ levels are maintained, SIRT3 restarts its biological functions and starts enhancing cellular energy production, helping you feel significantly more energetic, physically capable, and free from daily exhaustion.
Next, the Healthy Metabolism Gene (SIRT4) becomes active again.
This gene regulates how your body efficiently processes fats and sugars.
NMN/NAD+ boosts reactivates SIRT4, improving metabolism, decreasing fat storage, and stabilizing your daily energy.
You’ll feel lighter, notice fewer cravings, and maintain consistent energy levels throughout the day.
Maintaining NMN/NAD+ for weeks, the Detox & Immunity Strength Gene (SIRT5) reactivates.
SIRT5 supports cellular detoxification and immune health.
Once sufficiently active, this gene helps your body effectively clear toxins, strengthen immunity, and recover more quickly from stress and illness.
Sufficient NMN/NAD+ levels for months activates the Radiant Skin Repair Gene (SIRT6)
Specializing in repairing DNA damage related to skin aging, SIRT6 addresses oxidative stress, inflammation, and environmental toxins.
With SIRT6 active, you'll see smoother, firmer, more radiant skin, with visibly reduced wrinkles and a youthful glow.
Finally, after maintaining optimal NMN/NAD+ levels long-term, the Youthful Cell Renewal Gene (SIRT7) fully activates.
SIRT7 ensures healthy cell division and regeneration, promoting the continuous creation of vibrant, youthful cells.
Sustained NMN/NAD+ restarts SIRT7 gene that supports ongoing cellular health, helping maintain youthful tissues, organs, and an overall rejuvenated appearance.
With sustained NMN/NAD+ support, you'll start feeling and looking youthful again, experiencing greater longevity and vibrant, lasting health.
How We Created the Safest and Most Effective NAD/NMN Supplement to Reactivate Your Body’s Natural Anti-Aging Blueprint
At HumaSpan Research, we set out to understand the science of aging holistically. Partnering with world-renowned anti-aging and longevity experts, our goal was clear: create the most effective, scientifically validated solution to combat aging at its deepest cellular level.
Over the course of 24 months, our dedicated research team reviewed more than 500+ scientific studies, rigorously tested over 50+ key ingredients, and consulted extensively with leading aging researchers globally.
This extensive research confirmed that DNA damage and dormant anti-aging instructions within your cells can be naturally repaired and reactivated at any age simply by replenishing your body’s NAD+ levels using NMN supplements.
We invested over $450,000 in refining and perfecting our NAD+/NMN supplement formula, prioritizing maximum potency and absorption. To enhance nutrient uptake, we incorporated Bioperine, a powerful absorption enhancer.
At HumaSpan Research, we set out to understand the science of aging holistically. Partnering with world-renowned anti-aging and longevity experts, our goal was clear: create the most effective, scientifically validated solution to combat aging at its deepest cellular level.
Over the course of 24 months, our dedicated research team reviewed more than 500+ scientific studies, rigorously tested over 50+ key ingredients, and consulted extensively with leading aging researchers globally.
This extensive research confirmed that DNA damage and dormant anti-aging instructions within your cells can be naturally repaired and reactivated at any age simply by replenishing your body’s NAD+ levels using NMN supplements.
We invested over $450,000 in refining and perfecting our NAD+/NMN supplement formula, prioritizing maximum potency and absorption. To enhance nutrient uptake, we incorporated Bioperine, a powerful absorption enhancer.
Additionally, we included Betaine Anhydrous, a cellular hydrator that boosts metabolic function.
Before releasing it to everyone, we personally tested the supplement alongside friends, family, and private clients, achieving remarkable results.
Thousands of satisfied users now enjoy visibly improved energy, youthful skin, strengthened muscles, enhanced mental clarity, robust immunity, and a noticeable reduction in signs of aging.
We proudly named this breakthrough formula NADrive—a scientifically proven supplement specifically designed to repair DNA damage and reactivate your body's natural anti-aging instructions.
Additionally, we included Betaine Anhydrous, a cellular hydrator that boosts metabolic function.
Before releasing it to everyone, we personally tested the supplement alongside friends, family, and private clients, achieving remarkable results.
Thousands of satisfied users now enjoy visibly improved energy, youthful skin, strengthened muscles, enhanced mental clarity, robust immunity, and a noticeable reduction in signs of aging.
We proudly named this breakthrough formula NADrive—a scientifically proven supplement specifically designed to repair DNA damage and reactivate your body's natural anti-aging instructions.
Each batch of NADrive is manufactured in an FDA-approved facility and undergoes rigorous third-party testing for purity, potency, and safety. This guarantees that you receive the highest quality, safest, and most effective anti-aging supplement possible.
Introducing NADrive: The Purest, Safest, and Most Effective NMN/NAD Supplement
If you have any questions or doubts, please feel free to contact our founders and experts at hello@humaspan.com. We'll respond within 24 hours.
Meet Our Humaspan Founders
How To Use
If you have any questions or doubts, please feel free to contact our founders and experts at hello@humaspan.com. We'll respond within 24 hours.
FAQs
NAD+ is a coenzyme that plays a vital role in cellular functions, and can be found in every cell in the body. It has two primary functions; converting nutrients into energy, and regulating metabolic processes. Acting as an electron transporter, NAD+ facilitates various reactions and processes within our cells, working in tandem with NADH. It also regulates our sleep/wake cycle, or circadian rhythm.
NAD+ enables other molecules to perform their functions effectively, but as we age, levels of NAD+ decrease. This hinders the activities of various NAD (H) dependent enzymes in oxidative phosphorylation, TCA cycle, and glycolysis, resulting in lower ATP production. Additionally, it can affect levels of PARP and sirtuins, leading to the inactivation of certain downstream molecular pathways that play a role in DNA repair.
In other words, NAD+ is crucial for the proper functioning of the body, and its depletion can lead to a slower metabolic rate and less effective self-repair. Without NAD+, our cells will generate less energy, making it difficult for the body to carry out its functions. Therefore, the importance of NAD+ lies in its ability to help other beneficial molecules perform their jobs.
Exploring NMN and NAD+ for Mitigating Aging-Related Dysfunctions
Nicotinamide Mononucleotide (NMN) is the precursor of NAD+ that is naturally converted by the body into NAD+. NMN is more stable than NAD+ and increasing NMN levels has been shown to enhance NAD+ biosynthesis, which can help combat age-related dysfunctions.
Taking NMN is the optimal approach to increase NAD+ levels. NMN is more stable than NAD+ and can stably boost NAD+ pools for a longer duration. Increasing NMN has all the benefits of NAD+ and specifically helps with vision and hearing loss related to aging. Additionally, it promotes sirtuin genes, which activate longevity and anti-aging mechanisms.
There are only a few reliable suppliers of enzymatically produced NMN. Good quality NMN is highly-priced. One of the key things to look out for when choosing an NMN supplement is to choose 99.9% pharmaceutical-grade NMN from a reliable source. Another important factor in efficacy is proper dosing. In order for NMN or any supplement to be effective it must be properly dosed. There are plenty of underdosed supplements on the market. Infinium, NADrive and VitaSpan are meticulously dosed and formulated for optimal results.
Chronological age refers to the number of years you've been alive, while biological age is calculated based on physiological evidence of how old your cells and tissues are. Even if you are of a certain age, being healthy and fit can give you a lower biological age. On the other hand, if you lead a sedentary lifestyle or have chronic illnesses, your biological age may be higher than your chronological age. While chronological age is static and unchangeable, biological age can be influenced by lifestyle choices and supplementation.
Although there have been no human studies that specifically determine at what age one should start taking NAD+ supplements, current research recommends starting NAD+ supplementation around midlife, which could be as early as 30 years of age.
Taking NMN supplements daily can result in visible changes within two to three weeks, including increased energy and awareness. While the supplement starts working within fifteen minutes, the full benefits may not be physically noticeable until the two to three week mark. After consistent use, notable differences in both internal and external health may be observed.
You’ll immediately start to feel some of the short term benefits of NMN supplements within your first couple uses and they can consist of higher energy levels and also a greater awareness. After a few weeks of use, you should start to see some notable differences in how you look and feel, both internally and externally.
With the addition of NMN supplements to your daily routine, you may quickly feel a difference in your energy levels and metabolism. You may experience increased energy throughout the day and find it easier to remain active. This is the first indication that NMN is starting to work.
NMN requires time to activate its effects. It takes roughly three weeks for your body to acclimate to the supplement and begin absorbing the NMN molecules.
Around the 3-4 month mark, you should start to feel more profound effects. You will experience sustained and youthful energy, deeper and more restful sleep, and increased ability to focus. Additionally, some people will find it easier to recover from muscle soreness and bearable aching joints.
Research References
[1] Yoshino, J., et al., Cell Metab. 14: 528–536 (2011)-https://pubmed.ncbi.nlm.nih.gov/21982712/
[2] Mills, K. F. et al. Cell Metab. 24: 795–806 (2016)-https://pubmed.ncbi.nlm.nih.gov/28068222/
[3] Grozio, A., et al., Nature Metabolism 1: 47-57 (2019)-https://pubmed.ncbi.nlm.nih.gov/31131364/
[4] Irie, J., et al., Endocrine Journal 67 (2): 153-160 (2020)-https://pubmed.ncbi.nlm.nih.gov/31685720/
[5] Nomiyama, T., et al., The Journal of Biochemistry 171 (3): 325-338 (2021)-https://pubmed.ncbi.nlm.nih.gov/34865026/
[6] Fu, J., et al., J Biol Chem. 287 (29): 24460–24472 (2012)-https://pmc.ncbi.nlm.nih.gov/articles/PMC4417679/
[7] Okabe, K., et al., Frontiers in Nutrition 9: 868640 (2022)-https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.868640/full
[8] Janssens, G.E. et al., Nat Aging 2: 254–263 (2022)-https://pubmed.ncbi.nlm.nih.gov/37118369/
[9] Igarashi, M. et al., NPG Aging 8: 5 (2022)-https://pubmed.ncbi.nlm.nih.gov/35927255/
[10] Morita, Y. et al., Glycative Stress Research 9 (2): 33-41 (2022)-https://pmc.ncbi.nlm.nih.gov/articles/PMC9735188/
[11] Yoshino, M. et al., Science 372 (6547): 1224-1229 (2021)-https://pubmed.ncbi.nlm.nih.gov/33888596/
[12] Niu, K-M. et al., Frontiers in Nutrition 8: 756243 (2021)-https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.756243/full
Other References
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https://pubmed.ncbi.nlm.nih.gov/38102202/
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https://pmc.ncbi.nlm.nih.gov/articles/PMC5419884/
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https://pmc.ncbi.nlm.nih.gov/articles/PMC7494058/
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https://www.sciencedirect.com/science/article/pii/S0006291X24001256
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https://www.mdpi.com/1422-0067/24/3/2959?type=check_update&version=1
Media References
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Jennifer Aniston: In an interview with The Wall Street Journal, Aniston referred to her weekly NAD+ IV treatments as "the future. https://www.nad.com/news/nad-is-the-future-of-longevity-what-celebrities-are-doing-to-never-age
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Hailey Bieber: On an episode of "Keeping Up With The Kardashians," Bieber stated, "I'm going to NAD for the rest of my life, and I'm never going to age. https://www.nad.com/news/nad-is-the-future-of-longevity-what-celebrities-are-doing-to-never-age
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Joe Rogan: The podcast host and comedian has mentioned using NAD+ supplementation on his show, "The Joe Rogan Experience. https://www.springfieldwellnesscenter.com/nad-blog/celebrities-use-nad-who-uses-it-and-why/
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Justin Bieber: The pop star has been reported to use NAD+ IV therapy as part of his wellness regimen. https://www.springfieldwellnesscenter.com/nad-blog/celebrities-use-nad-who-uses-it-and-why/
Disclaimer: We are not endorsed or affiliated by Harvard, David Sinclair, NIH, WebMD, Forbes, Stanford University, Mayo Clinic, PubMed, Time or any of the articles, publications, or individuals mentioned on this website.