Back then, long workdays, family time, and personal hobbies never seemed to exhaust you.
Your mind stayed clear and sharp, sleep felt naturally refreshing, your metabolism kept pace, and your skin had a healthy glow—all without extra effort.
But as you’ve moved into your 40s,50s, and beyond, things likely feel different.
Energy is harder to come by, leaving you fatigued after tasks that once felt easy.
Brain fog makes it challenging to concentrate, while sleep struggles can leave you groggy in the morning.
Your metabolism has slowed down, making it tougher to maintain a healthy weight, and your skin may be showing signs of wear, losing its once youthful radiance.
It’s easy to assume this is just “normal aging”—maybe things will improve with more exercise, a stricter diet, or a new supplement.
But what if there’s a deeper reason behind these changes?
Groundbreaking research from Harvard’s top longevity expert, David Sinclair, has revealed that a vital molecule in your body—essential for energy production, cellular repair, and overall resilience—gradually declines as you age.
Back then, long workdays, family time, and personal hobbies never seemed to exhaust you.
Your mind stayed clear and sharp, sleep felt naturally refreshing, your metabolism kept pace, and your skin had a healthy glow—all without extra effort.
But as you’ve moved into your 40s,50s, and beyond, things likely feel different.
Energy is harder to come by, leaving you fatigued after tasks that once felt easy.
Brain fog makes it challenging to concentrate, while sleep struggles can leave you groggy in the morning.
Your metabolism has slowed down, making it tougher to maintain a healthy weight, and your skin may be showing signs of wear, losing its once youthful radiance.
It’s easy to assume this is just “normal aging”—maybe things will improve with more exercise, a stricter diet, or a new supplement.
But what if there’s a deeper reason behind these changes?
Groundbreaking research from Harvard’s top longevity expert, David Sinclair, has revealed that a vital molecule in your body—essential for energy production, cellular repair, and overall resilience—gradually declines as you age.
As its levels drop, signs of aging become more pronounced, affecting everything from stamina and focus to sleep quality, metabolism, and skin health.
The good news? Thousands of people have already discovered how to restore this crucial molecule to youthful levels, reclaiming the energy, mental clarity, restful sleep, metabolic balance, and vibrant skin they thought were long gone.
As its levels drop, signs of aging become more pronounced, affecting everything from stamina and focus to sleep quality, metabolism, and skin health.
The good news? Thousands of people have already discovered how to restore this crucial molecule to youthful levels, reclaiming the energy, mental clarity, restful sleep, metabolic balance, and vibrant skin they thought were long gone.
Groundbreaking research by Harvard's Professor David Sinclair has uncovered a critical molecule in our body that plays a vital role in maintaining youthfulness and energy—it's called NAD+.
In your 20s, NAD+ levels were at their peak, enabling your body to convert food into energy, repair damaged DNA, and keep your cells healthy.
These high levels also helped neutralize oxidative stress, free radicals, and inflammation—key factors that contribute to aging.
But as the years go by, your body becomes increasingly deficient in NAD+, and its levels begin to drop sharply, plummeting by 50% to 90%.
Groundbreaking research by Harvard's Professor David Sinclair has uncovered a critical molecule in our body that plays a vital role in maintaining youthfulness and energy—it's called NAD+.
In your 20s, NAD+ levels were at their peak, enabling your body to convert food into energy, repair damaged DNA, and keep your cells healthy.
These high levels also helped neutralize oxidative stress, free radicals, and inflammation—key factors that contribute to aging. But as the years go by, your body becomes increasingly deficient in NAD+, and its levels begin to drop sharply, plummeting by 50% to 90%.
After years of extensive research and rigorous testing, we developed NADrive, the most potent anti-aging supplement on the market.
NADrive features a powerful blend of three ingredients: NMN, Bioperine, and Betaine Anhydrous. A common challenge with NMN has always been its bioavailability—how well your body can absorb and use it.
Even if taken in the right amount, NMN can be poorly absorbed. To address this, we added Bioperine, a natural compound that enhances nutrient absorption, ensuring that your body gets the maximum benefit from NMN.
We also included Betaine Anhydrous, a compound that hydrates cells, improves metabolic function, and boosts energy. This unique blend not only elevates NAD+ levels but also enhances overall cellular health, ensuring you get the most out of every dose.
NADrive features a powerful blend of three ingredients: NMN, Bioperine, and Betaine Anhydrous. A common challenge with NMN has always been its bioavailability—how well your body can absorb and use it.
Even if taken in the right amount, NMN can be poorly absorbed. To address this, we added Bioperine, a natural compound that enhances nutrient absorption, ensuring that your body gets the maximum benefit from NMN.
We also included Betaine Anhydrous, a compound that hydrates cells, improves metabolic function, and boosts energy.
This unique blend not only elevates NAD+ levels but also enhances overall cellular health, ensuring you get the most out of every dose. Each batch is third-party tested to ensure quality and efficacy.
Each batch is third-party tested to ensure quality and efficacy.
With NADrive, you’re not just addressing the symptoms of aging—you’re tackling its root cause, allowing your body to thrive at every stage of life.
Studies suggest NMN supplementation can increase NAD+ levels in the body, potentially improving energy, metabolism and promoting cell repair
NMN shows promise in pre-clinical studies for various health benefits, particularly related to aging and age-related diseases
Betaine anhydrous shows potential for some health benefits, particularly related to homocysteine metabolism and liver health
Black pepper fruit extract (Bioperine) shows promise in enhancing nutrient absorption, offering potential benefits for overall health
At HumaSpan, our mission has always been to enhance the quality of life by leveraging the latest breakthroughs in scientific research.
From the beginning, as founders, we’ve dedicated ourselves to understanding the aging process and have collaborated with leading experts in the field to bring you the most effective solutions.
Initially, we discovered that taking NAD+ directly in the form of pills or supplements was ineffective because the stomach’s heat destroys NAD+, rendering it useless.
At HumaSpan, our mission has always been to enhance the quality of life by leveraging the latest breakthroughs in scientific research.
From the beginning, as founders, we’ve dedicated ourselves to understanding the aging process and have collaborated with leading experts in the field to bring you the most effective solutions.
Initially, we discovered that taking NAD+ directly in the form of pills or supplements was ineffective because the stomach’s heat destroys NAD+, rendering it useless. This realization led us to seek a better solution.
Harvard research revealed that a specific minimum dose of NMN (Nicotinamide Mononucleotide) is required to effectively boost NAD+ levels. Unlike direct NAD+ supplementation, NMN is a naturally occurring compound in all life forms and is a building block of NAD+.
Over time, studies have shown that NMN supplementation effectively boosts NAD+ levels. Because NMN is already present in our bodies and in some of the foods we eat, it’s recognized and safely metabolized by our system.
We found that most other supplements on the market sell low doses of NMN to reduce costs, making them ineffective.
This realization led us to seek a better solution.Harvard research revealed that a specific minimum dose of NMN (Nicotinamide Mononucleotide) is required to effectively boost NAD+ levels.
Unlike direct NAD+ supplementation, NMN is a naturally occurring compound in all life forms and is a building block of NAD+. Over time, studies have shown that NMN supplementation effectively boosts NAD+ levels.
Because NMN is already present in our bodies and in some of the foods we eat, it’s recognized and safely metabolized by our system.
We found that most other supplements on the market sell low doses of NMN to reduce costs, making them ineffective.
Understanding this, we developed NADrive with the optimal dose—1000mg of NMN—to ensure that your NAD+ levels are replenished effectively.
By consistently maintaining high levels of NMN, you ensure that your NAD+ levels remain elevated as you age.
As NAD+ levels stay high, cellular regeneration and repair are enhanced, leading to increased energy, sharper focus, a boosted metabolism, better quality sleep, and a stronger immune system—all the key components of youthful vitality and a radiant glow.
Understanding this, we developed NADrive with the optimal dose—1000mg of NMN—to ensure that your NAD+ levels are replenished effectively.
By consistently maintaining high levels of NMN, you ensure that your NAD+ levels remain elevated as you age.
As NAD+ levels stay high, cellular regeneration and repair are enhanced, leading to increased energy, sharper focus, a boosted metabolism, better quality sleep, and a stronger immune system—all the key components of youthful vitality and a radiant glow.
If you have any questions or doubts, please feel free to contact our founders and experts at hello@humaspan.com. We'll respond within 24 hours.
If you have any questions or doubts, please feel free to contact our founders and experts at hello@humaspan.com. We'll respond within 24 hours.
NAD+ is a coenzyme that plays a vital role in cellular functions, and can be found in every cell in the body. It has two primary functions; converting nutrients into energy, and regulating metabolic processes. Acting as an electron transporter, NAD+ facilitates various reactions and processes within our cells, working in tandem with NADH. It also regulates our sleep/wake cycle, or circadian rhythm.
NAD+ enables other molecules to perform their functions effectively, but as we age, levels of NAD+ decrease. This hinders the activities of various NAD (H) dependent enzymes in oxidative phosphorylation, TCA cycle, and glycolysis, resulting in lower ATP production. Additionally, it can affect levels of PARP and sirtuins, leading to the inactivation of certain downstream molecular pathways that play a role in DNA repair.
In other words, NAD+ is crucial for the proper functioning of the body, and its depletion can lead to a slower metabolic rate and less effective self-repair. Without NAD+, our cells will generate less energy, making it difficult for the body to carry out its functions. Therefore, the importance of NAD+ lies in its ability to help other beneficial molecules perform their jobs.
Exploring NMN and NAD+ for Mitigating Aging-Related Dysfunctions
Nicotinamide Mononucleotide (NMN) is the precursor of NAD+ that is naturally converted by the body into NAD+. NMN is more stable than NAD+ and increasing NMN levels has been shown to enhance NAD+ biosynthesis, which can help combat age-related dysfunctions.
Taking NMN is the optimal approach to increase NAD+ levels. NMN is more stable than NAD+ and can stably boost NAD+ pools for a longer duration. Increasing NMN has all the benefits of NAD+ and specifically helps with vision and hearing loss related to aging. Additionally, it promotes sirtuin genes, which activate longevity and anti-aging mechanisms.
There are only a few reliable suppliers of enzymatically produced NMN. Good quality NMN is highly-priced. One of the key things to look out for when choosing an NMN supplement is to choose 99.9% pharmaceutical-grade NMN from a reliable source. Another important factor in efficacy is proper dosing. In order for NMN or any supplement to be effective it must be properly dosed. There are plenty of underdosed supplements on the market. Infinium, NADrive and VitaSpan are meticulously dosed and formulated for optimal results.
Chronological age refers to the number of years you've been alive, while biological age is calculated based on physiological evidence of how old your cells and tissues are. Even if you are of a certain age, being healthy and fit can give you a lower biological age. On the other hand, if you lead a sedentary lifestyle or have chronic illnesses, your biological age may be higher than your chronological age. While chronological age is static and unchangeable, biological age can be influenced by lifestyle choices and supplementation.
Although there have been no human studies that specifically determine at what age one should start taking NAD+ supplements, current research recommends starting NAD+ supplementation around midlife, which could be as early as 30 years of age.
Taking NMN supplements daily can result in visible changes within two to three weeks, including increased energy and awareness. While the supplement starts working within fifteen minutes, the full benefits may not be physically noticeable until the two to three week mark. After consistent use, notable differences in both internal and external health may be observed.
You’ll immediately start to feel some of the short term benefits of NMN supplements within your first couple uses and they can consist of higher energy levels and also a greater awareness. After a few weeks of use, you should start to see some notable differences in how you look and feel, both internally and externally.
With the addition of NMN supplements to your daily routine, you may quickly feel a difference in your energy levels and metabolism. You may experience increased energy throughout the day and find it easier to remain active. This is the first indication that NMN is starting to work.
NMN requires time to activate its effects. It takes roughly three weeks for your body to acclimate to the supplement and begin absorbing the NMN molecules.
Around the 3-4 month mark, you should start to feel more profound effects. You will experience sustained and youthful energy, deeper and more restful sleep, and increased ability to focus. Additionally, some people will find it easier to recover from muscle soreness and bearable aching joints.
https://pubmed.ncbi.nlm.nih.gov/38102202/
https://sinclair.hms.harvard.edu/
Disclaimer: We are not endorsed or affiliated by Harvard, David Sinclair, NIH, WebMD, any of the articles, publications, or individuals mentioned on this website.