In your 20s, you could effortlessly pull all-nighters, whether for studying, working, or partying, bouncing back with little more than a strong coffee.
Your skin was radiant, and your energy seemed endless, allowing you to chase your dreams. In your 30s, you could see the first signs of fine lines and a slight loss of youthful elasticity in your skin.
As you enter your 40s and 50s, you might start feeling fatigued sooner and more frequently, even after a restful sleep. Some might experience brain fog and loss of focus.
Your skin, which used to be so firm, might start to lose that youthful elasticity. And the endless vibrant energy and youthful body you took for granted begins to fade.
You might think these changes are because we are "getting old," but we're here to tell you that aging doesn't have to mean diminished vitality, declining physical strength, or losing your youthful skin glow.
A recent Harvard study reveals that these age-related declines are not simply due to "getting older." They are linked to our bodies' diminished capacity to neutralize oxidative stress at the cellular level as we age.
This study discovered that many things we think of as 'just getting old,' including skin aging, can be slowed down and even turned around.
But to make that happen, we need to start actively taking care of our bodies, giving them what they need, starting from our 40s onwards.
Harvard's Professor David Sinclair shares some eye-opening insights on aging. He points out that aging isn't just about getting older. Over time, the epigenome—essentially the set of instructions for our cells—starts getting mixed up.
This confusion leads our cells to forget their functions, causing oxidative stress and cellular damage. He has discovered that a crucial molecule called NAD+, which is vital for cell function, cellular repair, neutralizing oxidative stress, maintaining the epigenome, DNA repair, and energy production, diminishes as we age.
This crucial research reveals that the depletion of NAD+ as we age is the key factor driving many age-related problems.
This molecule in our body called NAD+ is crucial for proper cell function. It also helps reduce oxidative stress, generate energy, and repair cells.
In our 20s, we have high levels of NAD+ (nicotinamide adenine dinucleotide), which helps neutralize free radicals and mitigate oxidative stress by facilitating repair and maintenance processes within cells.
As we age, NAD+ levels naturally decline. This NAD+ decline means our ability to repair cellular damage and maintain cellular functions decreases.
This drop in NAD+ levels is the primary reason behind the declines in energy, fitness, and skin elasticity in our 40s and 50s.
Imagine waking up tomorrow feeling super fresh and energetic, like you're all set to handle whatever comes your way. Your skin looks bright and smooth, and the fine lines on your face and around your eyes are less noticeable.
It feels like you're ready to take on anything. And as you go about your day, people can't help but notice and ask what your secret is to looking so fresh and young.
This could be your new reality, but only if we tackle the real problem behind aging that few people talk about. Slowing the aging process isn't about loading up on vitamins, applying anti-aging creams, or resorting to Botox! It's about healing the body from within and giving it what it needs the most!
Boosting NAD+ levels is critical to reversing many aspects of aging, rejuvenating cells, and enhancing overall health.
The big problem is that NAD+ isn't very stable with heat and doesn't work well in pills or supplements you swallow because it can break down in your stomach.
The best way to increase NAD+ is to take NMN (Nicotinamide Mononucleotide), a compound found naturally in all life forms. NMN supplementation has been shown to boost NAD+ levels for longer periods of time. NMN is quite safe.
It's already in our bodies and some of the foods we eat, so our system knows how to handle it well.
Once you manage your NMN levels, your NAD+ levels will remain high as you age. When your NAD+ levels are optimal, your body can manage and reverse many signs of aging.
At HumaSpan, our mission is driven by the latest research to significantly enhance the quality of life. As the founders of HumaSpan, we dove deep into aging research and sought insights from the best minds and top researchers.
After extensive research and testing, we have developed the purest and most potent form (1000mg) of NMN supplementation, NADrive, which is third-party tested and contains a combination of three powerful ingredients.
The problem with NMN is its bioavailability and absorption. Even if we take it in the correct quantity, our body cannot absorb it completely. To solve this problem, we added Bioperine to increase absorption. In addition, we included Betaine Anhydrous, which acts as a cellular hydrator, improves metabolic function, and boosts energy.
Studies suggest NMN supplementation can increase NAD+ levels in the body, potentially improving energy, metabolism and promoting cell repair
NMN shows promise in pre-clinical studies for various health benefits, particularly related to aging and age-related diseases
Betaine anhydrous shows potential for some health benefits, particularly related to homocysteine metabolism and liver health
Black pepper fruit extract (Bioperine) shows promise in enhancing nutrient absorption, offering potential benefits for overall health
If you have any questions or doubts, please feel free to contact our founders and experts at hello@humaspan.com. We'll respond within 24 hours.
By boosting NAD+ levels, NMN may help reverse some aging signs and improve cellular functions, potentially extending lifespan.
NMN is a precursor to NAD+, which is crucial for energy metabolism in cells. Higher NAD+ levels support enhanced energy production, which is vital for aging cells.
By promoting creatine synthesis and reducing fatigue, betaine may improve muscle performance and endurance, beneficial for aging adults to maintain physical activity levels.
Betaine may reduce oxidative stress and inflammation in the body, contributing to reduced aging signs and lower risk of chronic diseases.
NMN significantly elevates NAD+ levels, which is essential for cellular energy, DNA repair, and regulating the aging process. Neutralizing free radicals mitigates oxidative stress, enhancing cellular health and promoting longevity.
Betaine boosts energy and slows metabolic aging by supporting mitochondrial function and serving as a cellular hydrator. It also fights free radicals, prevents cell dehydration, and enhances nutrient absorption, crucial for overall health.
Bioperine improves the bioavailability and absorption of essential vitamins and minerals. Its antioxidant capabilities combat oxidative stress, supporting efforts against aging.
Disclaimer: We are not endorsed or affiliated by Harvard, David Sinclair, NIH, WebMD, any of the articles, publications, or individuals mentioned on this website.
If you have any questions or doubts, please feel free to contact our founders and experts at hello@humaspan.com. We'll respond within 24 hours.
NAD+ is a coenzyme that plays a vital role in cellular functions, and can be found in every cell in the body. It has two primary functions; converting nutrients into energy, and regulating metabolic processes. Acting as an electron transporter, NAD+ facilitates various reactions and processes within our cells, working in tandem with NADH. It also regulates our sleep/wake cycle, or circadian rhythm.
NAD+ enables other molecules to perform their functions effectively, but as we age, levels of NAD+ decrease. This hinders the activities of various NAD (H) dependent enzymes in oxidative phosphorylation, TCA cycle, and glycolysis, resulting in lower ATP production. Additionally, it can affect levels of PARP and sirtuins, leading to the inactivation of certain downstream molecular pathways that play a role in DNA repair.
In other words, NAD+ is crucial for the proper functioning of the body, and its depletion can lead to a slower metabolic rate and less effective self-repair. Without NAD+, our cells will generate less energy, making it difficult for the body to carry out its functions. Therefore, the importance of NAD+ lies in its ability to help other beneficial molecules perform their jobs.
Exploring NMN and NAD+ for Mitigating Aging-Related Dysfunctions
Nicotinamide Mononucleotide (NMN) is the precursor of NAD+ that is naturally converted by the body into NAD+. NMN is more stable than NAD+ and increasing NMN levels has been shown to enhance NAD+ biosynthesis, which can help combat age-related dysfunctions.
Taking NMN is the optimal approach to increase NAD+ levels. NMN is more stable than NAD+ and can stably boost NAD+ pools for a longer duration. Increasing NMN has all the benefits of NAD+ and specifically helps with vision and hearing loss related to aging. Additionally, it promotes sirtuin genes, which activate longevity and anti-aging mechanisms.
There are only a few reliable suppliers of enzymatically produced NMN. Good quality NMN is highly-priced. One of the key things to look out for when choosing an NMN supplement is to choose 99.9% pharmaceutical-grade NMN from a reliable source. Another important factor in efficacy is proper dosing. In order for NMN or any supplement to be effective it must be properly dosed. There are plenty of underdosed supplements on the market. Infinium, NADrive and VitaSpan are meticulously dosed and formulated for optimal results.
Chronological age refers to the number of years you've been alive, while biological age is calculated based on physiological evidence of how old your cells and tissues are. Even if you are of a certain age, being healthy and fit can give you a lower biological age. On the other hand, if you lead a sedentary lifestyle or have chronic illnesses, your biological age may be higher than your chronological age. While chronological age is static and unchangeable, biological age can be influenced by lifestyle choices and supplementation.
Although there have been no human studies that specifically determine at what age one should start taking NAD+ supplements, current research recommends starting NAD+ supplementation around midlife, which could be as early as 30 years of age.
Taking NMN supplements daily can result in visible changes within two to three weeks, including increased energy and awareness. While the supplement starts working within fifteen minutes, the full benefits may not be physically noticeable until the two to three week mark. After consistent use, notable differences in both internal and external health may be observed.
You’ll immediately start to feel some of the short term benefits of NMN supplements within your first couple uses and they can consist of higher energy levels and also a greater awareness. After a few weeks of use, you should start to see some notable differences in how you look and feel, both internally and externally.
With the addition of NMN supplements to your daily routine, you may quickly feel a difference in your energy levels and metabolism. You may experience increased energy throughout the day and find it easier to remain active. This is the first indication that NMN is starting to work.
NMN requires time to activate its effects. It takes roughly three weeks for your body to acclimate to the supplement and begin absorbing the NMN molecules.
Around the 3-4 month mark, you should start to feel more profound effects. You will experience sustained and youthful energy, deeper and more restful sleep, and increased ability to focus. Additionally, some people will find it easier to recover from muscle soreness and bearable aching joints.