By HumaSpan Research Team
March 17th 2025
Women Worldwide Including Top Celebrities Are Embracing All-Natural NAD+ Molecule to Reduce Visible Signs Of Aging Naturally
They are doing this because scientific research and clinical trials from Harvard, Mayo Clinic, PubMed, and the NIH have identified NAD+, a natural molecule in our body, as a key factor that determines how fast or slow we age.
This all-natural molecule NAD+ (Nicotinamide Adenine Dinucleotide) fuels cellular repair, energy production, DNA restoration, and longevity. NAD+ is the foundation of cellular health, sustaining youthful energy, radiant skin, and overall vitality.
Here are the key functions of NAD+ that help you look and feel younger while supporting vitality and longevity.
They are doing this because scientific research and clinical trials from Harvard, Mayo Clinic, PubMed, and the NIH have identified NAD+, a natural molecule in our body, as a key factor that determines how fast or slow we age.
This all-natural molecule NAD+ (Nicotinamide Adenine Dinucleotide) fuels cellular repair, energy production, DNA restoration, and longevity.
NAD+ is the foundation of cellular health, sustaining youthful energy, radiant skin, and overall vitality.
Here are the key functions of NAD+ that help you look and feel younger while supporting vitality and longevity.
✅ Repairs and Regenerates Cells: NAD+ naturally fuels cellular repair and promotes new cell generation, helping restore skin firmness, elasticity, and hydration while enhancing a healthy, radiant glow.
✅ Defends Against Oxidative Stress and Inflammation: NAD+ naturally combats free radicals and inflammation, helping reduce wrinkles, joint stiffness, and age-related decline while promoting smooth skin, flexible joints, faster recovery, and stronger muscle function.
✅ Boosts Energy, Immunity, and Mental Clarity: NAD+ naturally enhances cellular energy production, keeping you refreshed, focused, and active. It strengthens the immune system to help your body fight illness and recover faster, sharpening cognitive function for better focus, memory, and mental clarity.
✅ Repairs and Regenerates Cells: NAD+ naturally fuels cellular repair and promotes new cell generation, helping restore skin firmness, elasticity, and hydration while enhancing a healthy, radiant glow.
✅ Defends Against Oxidative Stress and Inflammation: NAD+ naturally combats free radicals and inflammation, helping reduce wrinkles, joint stiffness, and age-related decline while promoting smooth skin, flexible joints, faster recovery, and stronger muscle function.
✅ Boosts Energy, Immunity, and Mental Clarity: NAD+ naturally enhances cellular energy production, keeping you refreshed, focused, and active. It strengthens the immune system to help your body fight illness and recover faster, sharpening cognitive function for better focus, memory, and mental clarity.
However, as we age, NAD+ levels naturally decline by 50% to 90%, making it harder for the body to perform these key functions.
As NAD+ declines, skin loses elasticity and glow, energy levels drop, mental clarity fades, immunity weakens, and muscle strength reduces—accelerating both visible and internal signs of aging.
The good news is that scientific research confirms that NAD+ levels can be naturally restored at any age, helping the body reduce the visible signs of aging from within.
Thousands of people who have replenished their NAD+ levels report:
However, as we age, NAD+ levels naturally decline by 50% to 90%, making it harder for the body to perform these key functions.
As NAD+ declines, skin loses elasticity and glow, energy levels drop, mental clarity fades, immunity weakens, and muscle strength reduces—accelerating both visible and internal signs of aging.
✅ Smoother, glowing skin with fewer wrinkles
✅ Increased energy and stamina throughout the day
✅Sharper focus and improved mental clarity
✅ Stronger immunity and deeper, more restful sleep
By restoring NAD+ levels, you can help your body repair, protect, and sustain youthful vitality from the inside out, allowing you to look and feel your best at any age.
Your Skin Will Again Glow with Youthfulness as Your Body Rejuvenates from Within, Helping You Look and Feel Younger!
Let’s dive into the science behind how NAD+ works to help your body repair, restore, and slow the visible signs of aging.
When we are young, our bodies naturally produce high levels of NAD+ to repair damaged cells, maintain energy, and protect against inflammation—all of which keep skin firm and youthful, energy levels steady, and overall vitality strong.
However, as we age, NAD+ levels decline by up to 90%, making it harder for the body to regenerate cells, sustain energy, and defend against free radicals and inflammation—all of which accelerate aging.
As a result, skin loses its firmness and glow, fine lines and wrinkles appear, fatigue becomes persistent, brain fog sets in, joints feel stiff, and the immune system weakens.
At this stage, many turn to anti-aging creams, serums, supplements, or even cosmetic procedures, hoping to slow aging. However, most of these only provide surface-level solutions and fail to address the real cause—declining NAD+ levels.
However, as we age, NAD+ levels decline by up to 90%, making it harder for the body to regenerate cells, sustain energy, and defend against free radicals and inflammation—all of which accelerate aging.
As a result, skin loses its firmness and glow, fine lines and wrinkles appear, fatigue becomes persistent, brain fog sets in, joints feel stiff, and the immune system weakens.
At this stage, many turn to anti-aging creams, serums, supplements, or even cosmetic procedures, hoping to slow aging. However, most of these only provide surface-level solutions and fail to address the real cause—declining NAD+ levels.
The good news is that leading research and clinical trials from Harvard, Mayo Clinic, PubMed, and the NIH confirm that NAD+ levels can be naturally replenished at any age.
Once NAD+ levels are replenished, the body restores its natural ability to combat oxidative stress, free radicals, and inflammation. This reduces visible signs of aging and promotes a youthful, radiant appearance.
Here’s the 7-stage process through which NAD+ restores youthful vitality and visibly slows the signs of aging.
How NAD+ Works in Your Body to Naturally Slow Aging and Reduce Visible Signs of Aging
Recent clinical trials and extensive research from Harvard, Mayo Clinic, PubMed, and the NIH have identified NAD+ as a crucial molecule in slowing aging and reducing visible signs of aging naturally.
However, as we age, NAD+ levels decline, making it harder for the body to function optimally. To produce NAD+, your body needs NMN—an essential nutrient that fuels NAD+ production. Research shows that supplementing with 1000mg of NMN can significantly increase NAD+ levels, supporting healthy aging from within.
Here’s what happens in your body after taking 1000mg of NMN, according to science.
Our Journey: Creating the Most Potent and Safest Anti-Aging Supplement to Boost NAD+/NMN Levels...
At HumaSpan, we’ve always been committed to enhancing quality of life through cutting-edge scientific research.
Our journey began with a deep dive into the aging process, collaborating with top experts to develop the most effective solution for boosting NAD+ levels.
Early on, we discovered that taking NAD+ directly in supplement form was ineffective—stomach acids destroy it before it can be absorbed.
This led us to NMN (Nicotinamide Mononucleotide), a building block that our body uses to create NAD+.
Harvard research confirmed that a specific minimum dose of NMN is required to replenish NAD+ levels effectively.
After years of extensive research and rigorous testing, we developed NADrive, the most potent anti-aging supplement on the market.
At HumaSpan, we’ve always been committed to enhancing quality of life through cutting-edge scientific research.
Our journey began with a deep dive into the aging process, collaborating with top experts to develop the most effective solution for boosting NAD+ levels.
Early on, we discovered that taking NAD+ directly in supplement form was ineffective—stomach acids destroy it before it can be absorbed.
This led us to NMN (Nicotinamide Mononucleotide), a building block that our body uses to create NAD+.
Harvard research confirmed that a specific minimum dose of NMN is required to replenish NAD+ levels effectively.
After years of extensive research and rigorous testing, we developed NADrive, the most potent anti-aging supplement on the market.
Most supplements on the market contain low doses to cut costs, making them ineffective. That’s why we created NADrive with 1000mg of NMN, the optimal dose to restore NAD+ levels and support healthy aging.
Optimal NAD+ levels allow your body to repair cells, neutralize free radicals, and clear out damaged cells. This helps slow aging and promotes radiant skin, restful sleep, a strong immune system, sharper focus, and a balanced metabolism.
To ensure maximum absorption, we included Bioperine, which enhances nutrient uptake, and Betaine Anhydrous, which hydrates cells and supports metabolic function. Each batch of NADrive is third-party tested for purity and potency, ensuring you get the most effective formula available.
With NADrive, you’re not just masking the signs of aging—you’re addressing the root cause, helping your body stay strong, resilient, and full of vitality at every stage of life.
Most supplements on the market contain low doses to cut costs, making them ineffective.
That’s why we created NADrive with 1000mg of NMN, the optimal dose to restore NAD+ levels and support healthy aging.
Optimal NAD+ levels allow your body to repair cells, neutralize free radicals, and clear out damaged cells.
This helps slow aging and promotes radiant skin, restful sleep, a strong immune system, sharper focus, and a balanced metabolism.
To ensure maximum absorption, we included Bioperine, which enhances nutrient uptake, and Betaine Anhydrous, which hydrates cells and supports metabolic function. Each batch of NADrive is third-party tested for purity and potency, ensuring you get the most effective formula available.
With NADrive, you’re not just masking the signs of aging—you’re addressing the root cause, helping your body stay strong, resilient, and full of vitality at every stage of life.
Introducing NADrive: The Most Potent and Safest NAD+/NMN Supplement That Reduces Visible Signs Of Aging Naturally.
If you have any questions or doubts, please feel free to contact our founders and experts at hello@humaspan.com. We'll respond within 24 hours.
Meet Our Humaspan Founders
How To Use
If you have any questions or doubts, please feel free to contact our founders and experts at hello@humaspan.com. We'll respond within 24 hours.
FAQs
NAD+ is a coenzyme that plays a vital role in cellular functions, and can be found in every cell in the body. It has two primary functions; converting nutrients into energy, and regulating metabolic processes. Acting as an electron transporter, NAD+ facilitates various reactions and processes within our cells, working in tandem with NADH. It also regulates our sleep/wake cycle, or circadian rhythm.
NAD+ enables other molecules to perform their functions effectively, but as we age, levels of NAD+ decrease. This hinders the activities of various NAD (H) dependent enzymes in oxidative phosphorylation, TCA cycle, and glycolysis, resulting in lower ATP production. Additionally, it can affect levels of PARP and sirtuins, leading to the inactivation of certain downstream molecular pathways that play a role in DNA repair.
In other words, NAD+ is crucial for the proper functioning of the body, and its depletion can lead to a slower metabolic rate and less effective self-repair. Without NAD+, our cells will generate less energy, making it difficult for the body to carry out its functions. Therefore, the importance of NAD+ lies in its ability to help other beneficial molecules perform their jobs.
Exploring NMN and NAD+ for Mitigating Aging-Related Dysfunctions
Nicotinamide Mononucleotide (NMN) is the precursor of NAD+ that is naturally converted by the body into NAD+. NMN is more stable than NAD+ and increasing NMN levels has been shown to enhance NAD+ biosynthesis, which can help combat age-related dysfunctions.
Taking NMN is the optimal approach to increase NAD+ levels. NMN is more stable than NAD+ and can stably boost NAD+ pools for a longer duration. Increasing NMN has all the benefits of NAD+ and specifically helps with vision and hearing loss related to aging. Additionally, it promotes sirtuin genes, which activate longevity and anti-aging mechanisms.
There are only a few reliable suppliers of enzymatically produced NMN. Good quality NMN is highly-priced. One of the key things to look out for when choosing an NMN supplement is to choose 99.9% pharmaceutical-grade NMN from a reliable source. Another important factor in efficacy is proper dosing. In order for NMN or any supplement to be effective it must be properly dosed. There are plenty of underdosed supplements on the market. Infinium, NADrive and VitaSpan are meticulously dosed and formulated for optimal results.
Chronological age refers to the number of years you've been alive, while biological age is calculated based on physiological evidence of how old your cells and tissues are. Even if you are of a certain age, being healthy and fit can give you a lower biological age. On the other hand, if you lead a sedentary lifestyle or have chronic illnesses, your biological age may be higher than your chronological age. While chronological age is static and unchangeable, biological age can be influenced by lifestyle choices and supplementation.
Although there have been no human studies that specifically determine at what age one should start taking NAD+ supplements, current research recommends starting NAD+ supplementation around midlife, which could be as early as 30 years of age.
Taking NMN supplements daily can result in visible changes within two to three weeks, including increased energy and awareness. While the supplement starts working within fifteen minutes, the full benefits may not be physically noticeable until the two to three week mark. After consistent use, notable differences in both internal and external health may be observed.
You’ll immediately start to feel some of the short term benefits of NMN supplements within your first couple uses and they can consist of higher energy levels and also a greater awareness. After a few weeks of use, you should start to see some notable differences in how you look and feel, both internally and externally.
With the addition of NMN supplements to your daily routine, you may quickly feel a difference in your energy levels and metabolism. You may experience increased energy throughout the day and find it easier to remain active. This is the first indication that NMN is starting to work.
NMN requires time to activate its effects. It takes roughly three weeks for your body to acclimate to the supplement and begin absorbing the NMN molecules.
Around the 3-4 month mark, you should start to feel more profound effects. You will experience sustained and youthful energy, deeper and more restful sleep, and increased ability to focus. Additionally, some people will find it easier to recover from muscle soreness and bearable aching joints.
Research References
[1] Yoshino, J., et al., Cell Metab. 14: 528–536 (2011)-https://pubmed.ncbi.nlm.nih.gov/21982712/
[2] Mills, K. F. et al. Cell Metab. 24: 795–806 (2016)-https://pubmed.ncbi.nlm.nih.gov/28068222/
[3] Grozio, A., et al., Nature Metabolism 1: 47-57 (2019)-https://pubmed.ncbi.nlm.nih.gov/31131364/
[4] Irie, J., et al., Endocrine Journal 67 (2): 153-160 (2020)-https://pubmed.ncbi.nlm.nih.gov/31685720/
[5] Nomiyama, T., et al., The Journal of Biochemistry 171 (3): 325-338 (2021)-https://pubmed.ncbi.nlm.nih.gov/34865026/
[6] Fu, J., et al., J Biol Chem. 287 (29): 24460–24472 (2012)-https://pmc.ncbi.nlm.nih.gov/articles/PMC4417679/
[7] Okabe, K., et al., Frontiers in Nutrition 9: 868640 (2022)-https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.868640/full
[8] Janssens, G.E. et al., Nat Aging 2: 254–263 (2022)-https://pubmed.ncbi.nlm.nih.gov/37118369/
[9] Igarashi, M. et al., NPG Aging 8: 5 (2022)-https://pubmed.ncbi.nlm.nih.gov/35927255/
[10] Morita, Y. et al., Glycative Stress Research 9 (2): 33-41 (2022)-https://pmc.ncbi.nlm.nih.gov/articles/PMC9735188/
[11] Yoshino, M. et al., Science 372 (6547): 1224-1229 (2021)-https://pubmed.ncbi.nlm.nih.gov/33888596/
[12] Niu, K-M. et al., Frontiers in Nutrition 8: 756243 (2021)-https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.756243/full
Other References
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https://pubmed.ncbi.nlm.nih.gov/38102202/
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https://pmc.ncbi.nlm.nih.gov/articles/PMC5419884/
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https://pmc.ncbi.nlm.nih.gov/articles/PMC7494058/
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https://www.sciencedirect.com/science/article/pii/S0006291X24001256
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https://www.mdpi.com/1422-0067/24/3/2959?type=check_update&version=1
Media References
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Jennifer Aniston: In an interview with The Wall Street Journal, Aniston referred to her weekly NAD+ IV treatments as "the future. https://www.nad.com/news/nad-is-the-future-of-longevity-what-celebrities-are-doing-to-never-age
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Hailey Bieber: On an episode of "Keeping Up With The Kardashians," Bieber stated, "I'm going to NAD for the rest of my life, and I'm never going to age. https://www.nad.com/news/nad-is-the-future-of-longevity-what-celebrities-are-doing-to-never-age
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Joe Rogan: The podcast host and comedian has mentioned using NAD+ supplementation on his show, "The Joe Rogan Experience. https://www.springfieldwellnesscenter.com/nad-blog/celebrities-use-nad-who-uses-it-and-why/
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Justin Bieber: The pop star has been reported to use NAD+ IV therapy as part of his wellness regimen. https://www.springfieldwellnesscenter.com/nad-blog/celebrities-use-nad-who-uses-it-and-why/
Disclaimer: We are not endorsed or affiliated by Harvard, David Sinclair, NIH, WebMD, Forbes, Stanford University, Mayo Clinic, PubMed, Time or any of the articles, publications, or individuals mentioned on this website.