By HumaSpan Research Team
January 29th 2025
Doctors and researchers have discovered a powerful molecule in the body that plays a key role in how fast or slow you age. The more your body has, the slower you age. The less you have, the faster aging accelerates.
This molecule is NAD+ (Nicotinamide Adenine Dinucleotide). It is an essential molecule that fuels cellular repair, boosts energy production, supports DNA repair, and promotes longevity.
However, NAD+ levels decline with age, leading to accelerated signs of aging such as fatigue, poor sleep, premature wrinkles, brain fog, and weakened immunity.
Once you support your body’s ability to produce more NAD+ and restore its optimal levels, you can unlock powerful anti-aging benefits such as
Doctors and researchers have discovered a powerful molecule in the body that plays a key role in how fast or slow you age. The more your body has, the slower you age. The less you have, the faster aging accelerates.
This molecule is NAD+ (Nicotinamide Adenine Dinucleotide). It is an essential molecule that fuels cellular repair, boosts energy production, supports DNA repair, and promotes longevity.
However, NAD+ levels decline with age, leading to accelerated signs of aging such as fatigue, poor sleep, premature wrinkles, brain fog, and weakened immunity.
Once you support your body’s ability to produce more NAD+ and restore its optimal levels, you can unlock powerful anti-aging benefits such as
✅ Slows Aging – Fuels cellular repair and longevity
✅ Restores Youthful Energy – Fights fatigue and enhances vitality
✅ Reduces Wrinkles – Improves skin elasticity and radiance
✅ Enhances Focus – Sharpens memory and mental clarity
✅ Boosts Immunity – Strengthens the body’s natural defenses
✅ Improves Sleep Quality – Supports deeper, more restorative sleep
Remember when long workdays, time with family, and your favorite hobbies never left you feeling drained? Your mind was sharp, sleep was refreshing, your metabolism worked effortlessly, and your skin had a youthful glow—all without extra effort.
But as you move into your 40s, 50s, and beyond, things begin to change. Energy fades faster than expected, brain fog makes it harder to focus, and restful sleep becomes rare, leaving you groggy in the morning.
Your metabolism slows, making weight gain harder to control. Gut issues may become more frequent, and your skin starts losing its youthful firmness.
Joints feel stiff, recovery takes longer, and your immune system weakens, making you more prone to illness. At first, you might think this is just part of getting older.
But while aging is inevitable, feeling weak, drained, and sluggish doesn’t have to be. Scientists have identified a key reason behind these changes—declining NAD+ levels.
But as you move into your 40s, 50s, and beyond, things begin to change. Energy fades faster than expected, brain fog makes it harder to focus, and restful sleep becomes rare, leaving you groggy in the morning.
Your metabolism slows, making weight gain harder to control. Gut issues may become more frequent, and your skin starts losing its youthful firmness.
Joints feel stiff, recovery takes longer, and your immune system weakens, making you more prone to illness. At first, you might think this is just part of getting older.
But while aging is inevitable, feeling weak, drained, and sluggish doesn’t have to be. Scientists have identified a key reason behind these changes—declining NAD+ levels.
When we’re young, our bodies produce high levels of NAD+, a vital molecule responsible for cellular repair, energy production, and neutralizing free radicals. This keeps you resilient, energized, and youthful—even without focusing on diet, sleep, or self-care.
But as you move into your late 30s and beyond, NAD+ levels start to drop rapidly. By the time you reach your 40s and 50s, they can decline by as much as 50% to 90%.
With less NAD+, your body struggles to repair itself and protect against oxidative stress, accelerating aging. Energy declines, metabolism slows, and visible signs of aging—wrinkles, sagging skin, and joint pain—become more noticeable.
At this stage, many turn to anti-aging creams, serums, supplements, or even surgeries, hoping to slow aging. However, most of these only mask the symptoms rather than address the real cause—NAD+ depletion.
Without restoring NAD+ levels, your body can’t fight aging at a cellular level, and the effects only get worse with time.
But as you move into your late 30s and beyond, NAD+ levels start to drop rapidly. By the time you reach your 40s and 50s, they can decline by as much as 50% to 90%.
With less NAD+, your body struggles to repair itself and protect against oxidative stress, accelerating aging. Energy declines, metabolism slows, and visible signs of aging—wrinkles, sagging skin, and joint pain—become more noticeable.
At this stage, many turn to anti-aging creams, serums, supplements, or even surgeries, hoping to slow aging. However, most of these only mask the symptoms rather than address the real cause—NAD+ depletion.
Without restoring NAD+ levels, your body can’t fight aging at a cellular level, and the effects only get worse with time.
Recent clinical trials and medical research confirm that replenishing NAD+ levels naturally slows aging. NAD+ is one of the most significant breakthroughs in anti-aging science in over 100 years.
Studies from Harvard, Mayo Clinic, PubMed, and the NIH have shown its essential role in cellular repair, energy production, and protecting against the key drivers of aging.
As we age, NAD+ depletion weakens the body's ability to repair cells, restore DNA, and combat oxidative stress, free radicals, and inflammation—all major causes of accelerated aging.
It also affects mitochondrial function, metabolism, cognitive health, and immune strength, leading to increased fatigue, brain fog, and a decline in overall vitality.
However, research now shows that NAD+ levels can be restored naturally at any age, allowing your body to combat aging naturally.
When NAD+ levels are replenished, the body regains its ability to repair itself at the cellular level.
This allows your body to restore youthful energy, improve mental clarity, experience deeper sleep, balance metabolism, and support healthy, radiant skin.
Thousands of people have already used this breakthrough research to boost their NAD+ levels, which has made them look and feel younger.
Aging is inevitable, but feeling exhausted, sluggish, and weak doesn’t have to be.
By supporting NAD+ levels, your body can stay strong, resilient, and full of vitality at every stage of life.
When NAD+ levels are replenished, the body regains its ability to repair itself at the cellular level.
This allows your body to restore youthful energy, improve mental clarity, experience deeper sleep, balance metabolism, and support healthy, radiant skin.
Thousands of people have already used this breakthrough research to boost their NAD+ levels, which has made them look and feel younger.
Aging is inevitable, but feeling exhausted, sluggish, and weak doesn’t have to be.
By supporting NAD+ levels, your body can stay strong, resilient, and full of vitality at every stage of life.
At HumaSpan, we’ve always been committed to enhancing quality of life through cutting-edge scientific research.
Our journey began with a deep dive into the aging process, collaborating with top experts to develop the most effective solution for boosting NAD+ levels.
Early on, we discovered that taking NAD+ directly in supplement form was ineffective—stomach acids destroy it before it can be absorbed.
This led us to NMN (Nicotinamide Mononucleotide), a building block that our body uses to create NAD+.
Harvard research confirmed that a specific minimum dose of NMN is required to replenish NAD+ levels effectively.
After years of extensive research and rigorous testing, we developed NADrive, the most potent anti-aging supplement on the market.
At HumaSpan, we’ve always been committed to enhancing quality of life through cutting-edge scientific research.
Our journey began with a deep dive into the aging process, collaborating with top experts to develop the most effective solution for boosting NAD+ levels.
Early on, we discovered that taking NAD+ directly in supplement form was ineffective—stomach acids destroy it before it can be absorbed.
This led us to NMN (Nicotinamide Mononucleotide), a building block that our body uses to create NAD+.
Harvard research confirmed that a specific minimum dose of NMN is required to replenish NAD+ levels effectively.
After years of extensive research and rigorous testing, we developed NADrive, the most potent anti-aging supplement on the market.
Most supplements on the market contain low doses to cut costs, making them ineffective. That’s why we created NADrive with 1000mg of NMN, the optimal dose to restore NAD+ levels and support healthy aging.
Optimal NAD+ levels allow your body to repair cells, neutralize free radicals, and clear out damaged cells. This helps slow aging and promotes radiant skin, restful sleep, a strong immune system, sharper focus, and a balanced metabolism.
To ensure maximum absorption, we included Bioperine, which enhances nutrient uptake, and Betaine Anhydrous, which hydrates cells and supports metabolic function. Each batch of NADrive is third-party tested for purity and potency, ensuring you get the most effective formula available.
With NADrive, you’re not just masking the signs of aging—you’re addressing the root cause, helping your body stay strong, resilient, and full of vitality at every stage of life.
Most supplements on the market contain low doses to cut costs, making them ineffective.
That’s why we created NADrive with 1000mg of NMN, the optimal dose to restore NAD+ levels and support healthy aging.
Optimal NAD+ levels allow your body to repair cells, neutralize free radicals, and clear out damaged cells.
This helps slow aging and promotes radiant skin, restful sleep, a strong immune system, sharper focus, and a balanced metabolism.
To ensure maximum absorption, we included Bioperine, which enhances nutrient uptake, and Betaine Anhydrous, which hydrates cells and supports metabolic function. Each batch of NADrive is third-party tested for purity and potency, ensuring you get the most effective formula available.
With NADrive, you’re not just masking the signs of aging—you’re addressing the root cause, helping your body stay strong, resilient, and full of vitality at every stage of life.
If you have any questions or doubts, please feel free to contact our founders and experts at hello@humaspan.com. We'll respond within 24 hours.
If you have any questions or doubts, please feel free to contact our founders and experts at hello@humaspan.com. We'll respond within 24 hours.
NAD+ is a coenzyme that plays a vital role in cellular functions, and can be found in every cell in the body. It has two primary functions; converting nutrients into energy, and regulating metabolic processes. Acting as an electron transporter, NAD+ facilitates various reactions and processes within our cells, working in tandem with NADH. It also regulates our sleep/wake cycle, or circadian rhythm.
NAD+ enables other molecules to perform their functions effectively, but as we age, levels of NAD+ decrease. This hinders the activities of various NAD (H) dependent enzymes in oxidative phosphorylation, TCA cycle, and glycolysis, resulting in lower ATP production. Additionally, it can affect levels of PARP and sirtuins, leading to the inactivation of certain downstream molecular pathways that play a role in DNA repair.
In other words, NAD+ is crucial for the proper functioning of the body, and its depletion can lead to a slower metabolic rate and less effective self-repair. Without NAD+, our cells will generate less energy, making it difficult for the body to carry out its functions. Therefore, the importance of NAD+ lies in its ability to help other beneficial molecules perform their jobs.
Exploring NMN and NAD+ for Mitigating Aging-Related Dysfunctions
Nicotinamide Mononucleotide (NMN) is the precursor of NAD+ that is naturally converted by the body into NAD+. NMN is more stable than NAD+ and increasing NMN levels has been shown to enhance NAD+ biosynthesis, which can help combat age-related dysfunctions.
Taking NMN is the optimal approach to increase NAD+ levels. NMN is more stable than NAD+ and can stably boost NAD+ pools for a longer duration. Increasing NMN has all the benefits of NAD+ and specifically helps with vision and hearing loss related to aging. Additionally, it promotes sirtuin genes, which activate longevity and anti-aging mechanisms.
There are only a few reliable suppliers of enzymatically produced NMN. Good quality NMN is highly-priced. One of the key things to look out for when choosing an NMN supplement is to choose 99.9% pharmaceutical-grade NMN from a reliable source. Another important factor in efficacy is proper dosing. In order for NMN or any supplement to be effective it must be properly dosed. There are plenty of underdosed supplements on the market. Infinium, NADrive and VitaSpan are meticulously dosed and formulated for optimal results.
Chronological age refers to the number of years you've been alive, while biological age is calculated based on physiological evidence of how old your cells and tissues are. Even if you are of a certain age, being healthy and fit can give you a lower biological age. On the other hand, if you lead a sedentary lifestyle or have chronic illnesses, your biological age may be higher than your chronological age. While chronological age is static and unchangeable, biological age can be influenced by lifestyle choices and supplementation.
Although there have been no human studies that specifically determine at what age one should start taking NAD+ supplements, current research recommends starting NAD+ supplementation around midlife, which could be as early as 30 years of age.
Taking NMN supplements daily can result in visible changes within two to three weeks, including increased energy and awareness. While the supplement starts working within fifteen minutes, the full benefits may not be physically noticeable until the two to three week mark. After consistent use, notable differences in both internal and external health may be observed.
You’ll immediately start to feel some of the short term benefits of NMN supplements within your first couple uses and they can consist of higher energy levels and also a greater awareness. After a few weeks of use, you should start to see some notable differences in how you look and feel, both internally and externally.
With the addition of NMN supplements to your daily routine, you may quickly feel a difference in your energy levels and metabolism. You may experience increased energy throughout the day and find it easier to remain active. This is the first indication that NMN is starting to work.
NMN requires time to activate its effects. It takes roughly three weeks for your body to acclimate to the supplement and begin absorbing the NMN molecules.
Around the 3-4 month mark, you should start to feel more profound effects. You will experience sustained and youthful energy, deeper and more restful sleep, and increased ability to focus. Additionally, some people will find it easier to recover from muscle soreness and bearable aching joints.
https://pubmed.ncbi.nlm.nih.gov/38102202/
https://sinclair.hms.harvard.edu/
https://pmc.ncbi.nlm.nih.gov/articles/PMC5419884/
https://pmc.ncbi.nlm.nih.gov/articles/PMC7494058/
https://www.sciencedirect.com/science/article/pii/S0006291X24001256
https://www.mdpi.com/1422-0067/24/3/2959?type=check_update&version=1
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.056589
https://www.sciencedirect.com/science/article/pii/S2090123221001491
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